Mendelian randomization is not affected by the confounding inherent in observational studies but it does rely on several assumptions, which can be hard to test Mendelian randomization can provide a ...

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Mendelian randomization is a study design that uses genetic variants as instrumental variables to test the causal effect of a (non-genetic) risk factor on a disease or health-related outcome. Since ...

Studies have linked psoriasis and higher weight, but the causal relationship between the two has been unclear. What triggers what? Or could other underlying reasons explain the connection? "Higher BMI ...